Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ)

Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ)

Department of Animal Health. University of Córdoba

Ignacio García Bocanegra y Mª Ángeles Risalde Moya

Behind (from left to right): Jesús Barbero Moyano, María de los Ángeles Risalde Moya, Jorge Paniagua Risueño,
Adrián Beato Benítez, Tomás Fajardo Alonso,Ignacio García Bocanegra, Moisés Gonzálvez Juan, Irene Agulló Ros
David Cano Terriza, Leonor Muñoz Fernández.
Frontline (from left to right): Salvador Rejón Segura, Carlos Herrera Ortega, Daniel Bravo Barriga
Mario Frías Casas, Débora Jiménez Martín, Sabrina Castro Scholten, Borja Nadales Martín
Members not included in the photograph: Remigio Martínez Pérez, Saúl Jiménez Ruiz, Javier Caballero Gómez
Jose Carlos G. Villamandos, Antonio Arenas Casas

The GISAZ Group (Zoonosis and Animal Health Research Group) belongs to the UCO (University of Cordoba). GISAZ is an interdisciplinary group with more than 25 years of experience in Animal Health. This group is included within CIBERINFEC and Competitive Research Unit in Zoonoses and Emerging Diseases (ENZOEM) at UCO. It is integrated by researchers and professors of the UCO, including epidemiologists, pathologists, molecular biologists and specialists in the diagnosis and control of transmissible diseases in wild and domestic species.

MAIN RESEARCH LINES

• Epidemiological studies of zoonotic diseases. Within this line we are evaluating the role of different domestic, peridomestic and wild species, and the risk factors involved in the transmission of bacterial, viral and parasitic zoonotic diseases (tuberculosis, salmonellosis, tularemia, borreliosis, flavivirosis, hepatitis E, influenza virus, Crimean-Congo, Mers-Cov, SARS-Cov, avian influenza, toxoplasmosis, leishmaniasis, piroplasmosis, diseases caused by protists or trichinosis, among others) from a One Health perspective.
• Epidemiological study of transmissible diseases of importance in animal health. This line of research studies the impact of different emerging and re-emerging diseases in domestic and wild animal populations (myxomatosis, rabbit hemorrhagic viral disease, pestivirosis, paratuberculosis, bluetongue, Schmallenberg disease, among others) from a One Health perspective, determining the risk factors involved in the transmission and maintenance of these diseases,.
• Immunopathogenesis and diagnosis of zoonoses and emerging diseases. This line of research is focused on the inquiry of the pathogenesis and diagnosis of diseases like as tuberculosis, hepatitis E, leishmania, herpesvirus, SARS-Cov, pestivirosis, paratuberculosis or epizootic hemorrhagic disease. This line is based on the application between immunopathologic methods in experimental and observational models to understand the interactions of hosts and pathogens, as well as develop innovative immunodiagnostic tools.
• Development and evaluation of immunostimulants for the specific and non-specific fight against different infectious agents. This focused on valuate the protection of vaccines and design new vaccine strategies in disease of interest on diseases of importance in public health and animal health such as tuberculosis, leishmaniosis, paratuberculosis, flavovirosis and SARS-Cov) Moreover, we work in immunoprofilixis from the concept of trained immunity to explore the extent and efficacy of this non-specific protection due to inactivated mycobacteria, as well as to discover the immunological mechanisms involved in this protection against a wide range of zoonotic agents: bacterial (Salmonella and Borrrelia) and parasitic (Leishmania and Plasmodium).

AFFILIATION

Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ)
Department of Animal Health. University of Córdoba (ROR-ID 05yc77b46)
Córdoba, Andalucía, Spain
https://linktr.ee/gisaz?utm_source=linktree_profile_share&ltsid=da085c85-68e3-49e3-b10f-5a71ec1b6aff

CONTRIBUTIONS AND SELECTED PUBLICATIONS

1. Baz-Flores, S., Herraiz, C., Peralbo-Moreno, A., Barral, M., Arnal, M. C., Balseiro, A., Cano-Terriza, D., Castro-Scholten, S., Cevidanes, A., Conde-Lizarralde, A., Cuadrado-Matías, R., Escribano, F., de Luco, D. F., Fidalgo, L. E., Hermoso-de Mendoza, J., Fandos, P., Gómez-Guillamón, F., Granados, J. E., Jiménez-Martín, D., López-Olvera, J. R., Martín, I., Martínez, R., Mentaberre, G., García-Bocanegra, I., Ruiz-Fons, F. (2024). Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model. Ticks and tick-borne diseases, 15(1), 102281. https://doi.org/10.1016/j.ttbdis.2023.102281
2. Castro-Scholten, S., Caballero-Gómez, J., Rivero-Juárez, A., Cano-Terriza, D., Gómez-Guillamón, F., Jiménez-Martín, D., Rivero, A., García-Bocanegra, I. (2023). Monitoring of Hepatitis E Virus in Wild Lagomorphs in Spanish Mediterranean Ecosystems. Transboundary and Emerging Diseases, 2023. https://doi.org/10.1155/2023/7947220
3. Gonzálvez, M., Franco, J. J., Barbero-Moyano, J., Caballero-Gómez, J., Ruano, M. J., Martínez, R., Cano-Terriza, D., & García-Bocanegra, I. (2023). Monitoring the epidemic of West Nile virus in equids in Spain, 2020-2021. Preventive veterinary medicine, 217, 105975. https://doi.org/10.1016/j.prevetmed.2023.105975
4. Almería, S., Cabezón, O., Paniagua, J., Cano-Terriza, D., Jiménez-Ruiz, S., Arenas-Montes, A., … & García- Bocanegra, I. (2018). Toxoplasma gondii in sympatric domestic and wild ungulates in the Mediterranean ecosystem. Parasitology Research, 117(3), 665-671.
5. García-Bocanegra, I., Cano-Terriza, D., Vidal, G., Rosell, R., Paniagua, J., Jiménez-Ruiz, S., … & Pujols, J. (2017). Monitoring of Schmallenberg virus in Spanish wild artiodactyls, 2006–2015. PloS one, 12(8).
6. Cano-Terriza, D., Risalde, M.A., Rodríguez-Hernández, P., Napp, S., Fernández-Morente, M., Moreno, I., … & García-Bocanegra, I. (2018). Epidemiological surveillance of Mycobacterium tuberculosis complex in extensively raised pigs in the south of Spain. Preventive Veterinary Medicine, 159, 87-91.
7. Caballero-Gómez, J., Rivero-Juárez, A., Cano-Terriza, D., Fajardo, T., Buono, F., Jose-Cunilleras, E., García, J., Alguacil, E., Rivero, A., & García-Bocanegra, I. (2023). Epidemiological survey and risk factors associated with Paslahepevirus balayani in equines in Europe. One health (Amsterdam, Netherlands), 17, 100619. https://doi.org/10.1016/j.onehlt.2023.100619
8. Buffoni, L., Cano-Terriza, D., Jiménez-Martín, D., Jiménez-Ruiz, S., Martínez-Moreno, Á., Martínez-Moreno, F. J., Zafra, R., Pérez-Caballero, R., Risalde, M. Á., Gómez-Guillamón, F., & García-Bocanegra, I. (2024). Serosurveillance of Trichinella sp. in wild boar and Iberian domestic suids in Mediterranean ecosystems of southwestern Spain. Zoonoses and public health, 71(2), 191–199. https://doi.org/10.1111/zph.13098
9. Ferreras-Colino, E., Moreno, I., Gortázar, C., Sevilla, I., Agulló-Ros, I., Domínguez, L., Juste, R., Risalde, M. A., & Domínguez, M. (2023). Oral immunization with heat-inactivated Mycobacterium bovis reduces local parasite dissemination and hepatic granuloma development in mice infected with Leishmania amazonensis. Research in veterinary science, 162, 104963. https://doi.org/10.1016/j.rvsc.2023.104963
10. Jiménez-Ruiz, S., Arenas-Montes, A., Cano-Terriza, D. et al. Blood extraction method by endocranial venous sinuses puncture in hunted wild ruminants. Eur J Wildl Res 62, 775–780 (2016). https://doi.org/10.1007/s10344-016-1056-3
11. Vaz-Rodrigues R, Ferreras-Colino E, Ugarte-Ruíz M, Pesciaroli M, Thomas J, García-Seco T, Sevilla IA, Pérez-Sancho M, Mateo R, Domínguez L, Gortazar C, Risalde MA. Nonspecific protection of heat-inactivated Mycobacterium bovis against Salmonella Choleraesuis infection in pigs. Vet Res. 2022 Apr 18;53(1):31. doi: 10.1186/s13567-022-01047-8.
12. Agulló-Ros I, Jiménez-Martín D, Camacho-Sillero L, Gortázar C, Capucci L, Cano-Terriza D, Zorrilla I, Gómez-Guillamón F, García-Bocanegra I, Risalde MA. Pathological changes and viral antigen distribution in tissues of Iberian hare (Lepus granatensis) naturally infected with the emerging recombinant myxoma virus (ha-MYXV). Vet Rec. 2023 Jan;192(1):e2182. doi: 10.1002/vetr.2182.
13. Thomas J, Infantes-Lorenzo JA, Moreno I, Cano-Terriza D, de Juan L, García-Bocanegra I, Domínguez L, Domínguez M, Gortázar C, Risalde MA.Validation of a new serological assay for the identification of Mycobacterium tuberculosis complex-specific antibodies in pigs and wild boar. Prev Vet Med. 2019 Jan 1;162:11-17. doi: 10.1016/j.prevetmed.2018.11.004.
14. Roy Á, Risalde MA, Bezos J, Casal C, Romero B, Sevilla I, Díez-Guerrier A, Rodríguez-Bertos A, Domínguez M, Garrido J, Gortázar C, Domínguez L. Response of goats to intramuscular vaccination with heat-killed Mycobacterium bovis and natural challenge. Comp Immunol Microbiol Infect Dis. 2018 Oct;60:28-34. doi: 10.1016/j.cimid.2018.09.006.
15. Risalde MA, Molina AM, Lora AJ, Ayala N, Gómez-Villamandos JC, Moyano MR. Immunohistochemical expression of aromatase cyp19a1a and cyp19a1b in the ovary and brain of zebrafish (Danio rerio) exposed to different concentrations of bisphenol A. Aquat Toxicol. 2021 Aug;237:105876. doi: 10.1016/j.aquatox.2021.105876.