Skip to content

Pre-doctoral contracts at the CIB on the topic of resistance to antibiotics and protein nanotechnology

Calls / job

CIB
Posted on 01/17/2023
Business: Biological Research Center - CSIC
Province: Madrid

Call of the AEI for Aid for pre-doctoral contracts for the training of doctors 2022
Tackling antibiotic resistance: new antimicrobials through nanotechnology and protein engineering

The Margarita Salas Biological Research Center of the Higher Council for Scientific Research (CIB-CSIC, Madrid) seeks candidates with motivation and initiative to access one of the Grants for pre-doctoral contracts for the training of doctors 2022 from the State Research Agency (AEI). Candidates will acquire a comprehensive and complete training plan, with a set of multidisciplinary competence that include, from the understanding of the structure and folding of proteins, to nanotechnology and microbiology, with the final objective of applying the results in the biomedical field.

1) Contract reference: CEX2021-001226-S-20-6

Title: Solenoid beta-beta domains as tools for molecular recognition of polymers: use as antimicrobials of respiratory pathogens and in dental health.

Program: Biotechnology for Human Health

Responsible: Jesus M. Sanz and javier canada

Resume: The structure beta-beta solenoide (BBS) it is a type of folding only studied in depth in pathogen surface proteins Streptococcus pneumoniae (pneumococcus). However, this same folding exists in several proteins involved in the recognition of various polysaccharides. The aim of this thesis is, firstly, to use native BBS modules (isolated or immobilized on nanoparticles) to control biofilms of dental plaque microorganisms by competition with the parental proteins from which they come, and secondly, to generate a library of mutants from which select new polypeptides that specifically recognize the surface of pathogens such as Streptococcus mutans O Pseudomonas aeruginosa. Estos dominios servirían para la creación "a la carta" de enzimas líticas híbridas de la pared bacteriana (enzymes) and that would make it possible to combat more effectively the growing phenomenon of antibiotic resistance. In all cases, the structural analysis of BBS-carbohydrate complexes by low-resolution (circular dichroism, fluorescence) and high-resolution (NMR) techniques will allow the molecular characterization of the type of interaction between the protein and its ligand and help in its application as antimicrobials. .

2) Contract reference: CEX2021-001226-S-20-10

Title: Design of new antimicrobials by synthetic biology and nanobiotechnology: the bacterial envelope as a target.

Program: Understanding cellular machines

Responsible: German Rivas and Jesus M. Sanz

Resume: Determinadas horquillas-β ("choline-binding repeats" o CBRs) pertenecientes al módulo de unión a colina C-LytA del patógeno respiratorio Streptococcus pneumoniae (pneumococcus)are capable of suffering unusual transition βa in the presence of micelles. Furthermore, these CBRs show antimicrobial activity against pneumococcus by destabilizing its membrane. The topic of the thesis consists of the biophysical study of the interaction of CBRs with minimal membrane systems (nanodiscs, microdroplets, microspheres) and in the investigation of their possible accumulation in vivo in intracellular microenvironments with phase separation, with a triple objective: i) Investigate the possible biological relevance of the aforementioned β transitiona; ii) utilizar mutantes de C-LytA que muestren una interacción mejorada con lípidos como "tags" para la functionalization of lipid nanoparticles with recombinant proteins, and iii) the use of C-LytA-derived peptides and polypeptides as antimicrobial agents against various pathogens. In parallel, the use of multivalent nanoparticles for the modulation / inhibition of processes of the division of Streptococcus pneumoniae mediated by FtsZ (the control of FtsZ assembly, the formation of biomolecular condensates, or the interaction with other elements of the division machinery).

Selection process

Send to jmsanz@cib.csic.es one expression of interest before January 24, 2022 consisting of a letter of motivation, references and a the course of life Complete, including the academic record. Regarding the requirements, candidates are recommended to have a detailed reading of the call.

Play Video

Privacy Policy

This website is owned by the SPANISH SOCIETY OF MICROBIOLOGY, whose identification data are the following:

  • Center for Biological Research (CIB-CSIC)
  • c / Ramiro de Maeztu, 9 28040 Madrid.
  • Phone. 91 561 33 81 - Fax. 91 561 32 99
  • National Registry of Associations with the national number 579
  • CIF: G28648871

1. INFORMATION AND CONSENT.

By accepting this Privacy Policy, the User is informed and gives their free, informed, specific and unequivocal consent so that the personal data provided through this website (hereinafter, the "Website") are processed by SEM.

2. OBLIGATORY TO PROVIDE THE DATA.

The data requested in the web forms are generally mandatory (unless otherwise specified in the required field) to fulfill the established purposes. Therefore, if they are not provided or are not provided correctly, they will not be able to be attended to, without prejudice to the fact that you can freely view the content of the Website.

3. FOR WHAT PURPOSE WILL THE USER'S PERSONAL DATA BE PROCESSED AND FOR HOW LONG?

The personal data provided through the Website will be processed by SEM in accordance with the following purposes:

  • Manage and process the registration requests of new members, from the "new members" forms, as well as manage the fees and derived charges.
  • Periodically send members, including by electronic means, information, events or news that may be of interest to them, if the future member gives their consent by checking the corresponding check box, or, where appropriate, opposes or revokes their consent.

4. WHAT USER DATA WILL BE PROCESSED?

SEM will process the following categories of User data:

  • Identification data: name, surname and ID.
  • Contact information: postal address, email address and telephone.
  • Professional data: workplace and professional contact details.
  • Academic data: degree and specialization.
  • Billing information.

5. WHAT IS THE LEGITIMATION OF THE PROCESSING OF USER DATA?

The treatment of the User's data by the SEM is based on the consent that is requested and that you can withdraw at any time. However, in case of withdrawing your consent, this will not affect the legality of the treatments carried out previously.
The consents obtained for the aforementioned purposes are independent so that the User may revoke only one of them, not affecting the others.

6. TO WHICH RECIPIENTS WILL THE USER DATA BE COMMUNICATED?

The data of the partners may be communicated to the following companies in the cases indicated:

• To the corresponding banking entities in order to manage the collection of direct debit bills.

The User's data will not be communicated to any other entity, except legal obligation.

7. RESPONSIBILITY OF THE USER.

The User and the Candidate for membership:
- Guarantees that you are over 18 years of age and that the data you provide to the SEM is true, accurate, complete and updated. For these purposes, the User is responsible for the veracity of all the data that he communicates and will keep the information provided suitably updated, in such a way that it responds to his real situation.
- You will be responsible for the false or inaccurate information that you provide through the Website and for the direct or indirect damages that this causes to the SEM or to third parties.

8. COMMUNICATIONS.

One of the purposes for which the SEM processes the personal data provided by Users is to send them electronic communications with information related to congresses and other events, grant programs, scientific dissemination, awards or relevant news for the recipients.
In the event that the recipient wishes to stop receiving informative communications from the SEM, they can request the cancellation of the service by sending an email to secretaria.sem@semicrobiologia.com or by clicking on the "unsubscribe" link included in the communications.

9. EXERCISE OF RIGHTS.

The User can send a letter at any time and free of charge to the SEM, Centro de Investigaciones Biológicas (CIB-CSIC) - c / Ramiro de Maeztu, 9 28040 Madrid, attaching a photocopy of their identity document, to request their rights of access, rectification, deletion, opposition, limitation, portability of your data.
You can also complain to the Spanish Agency for Data Protection, through the following address: Spanish Agency for Data Protection, C / Jorge Juan, 6, 28001-Madrid, when the interested party considers that the SEM has violated the rights that They are recognized by the applicable regulations on data protection.

10. SECURITY MEASURES.

The SEM will treat the data of Users, Candidates and Partners at all times in an absolutely confidential manner and keeping the mandatory duty of secrecy regarding them, in accordance with the provisions of the applicable regulations, adopting technical measures and measures for this purpose. necessary organizational measures that guarantee the security of your data and prevent its alteration, loss, treatment or unauthorized access, taking into account the state of technology, the nature of the stored data and the risks to which they are exposed.

Request enrollment in the course Pre-doctoral contracts at the CIB on the subject of resistance to antibiotics and protein nanotechnology