Skip to content

Molecular biology of the pathogenicity of Brucella

Specialized Group:

Felix Sangari and Juan M Garcia Lobo

Institute of Biomedicine and Biotechnology. University of Cantabria-CSIC

Felix Sangari and Juan M Garcia Lobo

Group photo. Felix Sangari and Juan M Garcia Lobo

Felix Sangari and Juan M Garcia Lobo Brucella Felix Sangari and Juan M Garcia Lobohttp://web.unican.es/ibbtec/Felix Sangari and Juan M Garcia Lobo

Our main line of work is the investigation of the mechanisms of pathogenicity, or what has been the same, of the intracellular growth capacity of the important zoonotic agent Brucella.

Our main line of work is the investigation of the mechanisms of pathogenicity, or what has been the same, of the intracellular growth capacity of the important zoonotic agent Brucella They cause brucellosis, a zoonosis with significant repercussions on human animal health and which causes significant economic losses, with special repercussions in developing countries. In animals, which are their natural host, such as cows, goats or sheep, they mainly give rise to abortions and infertility, while in humans the disease manifests as a febrile syndrome that can progress to a chronic phase characterized by the appearance of severe complications such as endocarditis, arthralgia, epididymitis or neurobrucellosis. Brucellosis is endemic in areas such as Central and South America, the Middle East, the Mediterranean countries, North Africa, and the countries of the Caucasus and Central Asia. In Cantabria, an area with important cattle ranching under extensive management, occasional outbreaks still occur from time to time that require the sanitation of the affected herds, although the number of human cases is very low. However, the figure of some 500,000 new human cases each year is managed worldwide, a figure probably underestimated 4 or 5 times.

Our work on Brucella Our work on

Our work on Brucella Our work on2Our work on2 Our work on et al. 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of Brucella . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of

. 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of Brucella . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of. 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of Brucella. For this we have used bioinformatic prediction methods together with different strategies with cell microbiology methodology using fluorescent surrogate effectors or by viral interference methods.

. For this we have used bioinformatic prediction methods together with different strategies with cell microbiology methodology using fluorescent surrogate effectors or by viral interference methods. Brucella. For this we have used bioinformatic prediction methods together with different strategies with cell microbiology methodology using fluorescent surrogate effectors or by viral interference methods.

Regarding the studies in the Altamira cave, of the different biological risks detected, the proliferation of "visible colonies" is the one considered most relevant and to which we are devoting our research effort.

The so-called visible colonies in quotes are biofilms or consortia of microorganisms, generally a few millimeters in size, visible and with different colors (grey, white, yellow) that grow on the walls and ceiling, especially in the outermost areas of Altamira. Since their first description around the year 2000, they have been the subject of numerous studies. After our incorporation to this work, we are contributing to a better description of the components of the consortia through massive sequencing studies. After a characterization by sequencing of 16S RNA amplicons, we have progressed to a stage of metagenomic analysis that is beginning to give interesting results. We have data on the bacteria that make up the majority consortia and their proportions in the different types of "colony" and we have obtained good quality drafts of the genomes of the majority components derived from metagenomic data.

With this information, which we want to complete with expression data (metatranscriptomes), we hope to be able to identify the most relevant aspects of the ecology of the consortia, identify the energy sources and the metabolic pathways involved.

The ultimate goal of this work is the design of safe control measures that serve to tackle a possible problem of biodeterioration due to the overproliferation of "colonies" but that do not cause collateral problems of alternative proliferation, as has happened previously in similar circumstances. This objective, which is quite complicated, will only be possible when we know in detail the eco-physiological aspects of these consortia, to which we are dedicating our efforts.

The ultimate goal of this work is the design of safe control measures that serve to tackle a possible problem of biodeterioration due to the overproliferation of "colonies" but that do not cause collateral problems of alternative proliferation, as has happened previously in similar circumstances. This objective, which is quite complicated, will only be possible when we know in detail the eco-physiological aspects of these consortia, to which we are dedicating our efforts.The ultimate goal of this work is the design of safe control measures that serve to tackle a possible problem of biodeterioration due to the overproliferation of "colonies" but that do not cause collateral problems of alternative proliferation, as has happened previously in similar circumstances. This objective, which is quite complicated, will only be possible when we know in detail the eco-physiological aspects of these consortia, to which we are dedicating our efforts.

 

References

The ultimate goal of this work is the design of safe control measures that serve to tackle a possible problem of biodeterioration due to the overproliferation of "colonies" but that do not cause collateral problems of alternative proliferation, as has happened previously in similar circumstances. This objective, which is quite complicated, will only be possible when we know in detail the eco-physiological aspects of these consortia, to which we are dedicating our efforts. (2014). Molecular Biology of the Pathogenicity of Brucella(2014). Molecular Biology of the Pathogenicity of

(2014). Molecular Biology of the Pathogenicity of (2014). Molecular Biology of the Pathogenicity of(2014). Molecular Biology of the Pathogenicity of

(2014). Molecular Biology of the Pathogenicity of(2014). Molecular Biology of the Pathogenicity of Brucella (2014). Molecular Biology of the Pathogenicity of2 (2014). Molecular Biology of the Pathogenicity of in vivo(2014). Molecular Biology of the Pathogenicity of

(2014). Molecular Biology of the Pathogenicity of(2014). Molecular Biology of the Pathogenicity of http://www.culturaydeporte.gob.es/mnaltamira/dam/jcr:23aff8fe-2c0c-474a-8db4-c34b644bcde9/conservacionpreventivaaltamira-informefinal-doc-investigacion.pdf

(2014). Molecular Biology of the Pathogenicity of(2014). Molecular Biology of the Pathogenicity of (2014). Molecular Biology of the Pathogenicity of:281-90. doi: 10.1111/j.1574-6941.2012.01391.x.

Play Video

Privacy Policy

This website is owned by the SPANISH SOCIETY OF MICROBIOLOGY, whose identification data are the following:

  • Center for Biological Research (CIB-CSIC)
  • c / Ramiro de Maeztu, 9 28040 Madrid.
  • Phone. 91 561 33 81 - Fax. 91 561 32 99
  • National Registry of Associations with the national number 579
  • CIF: G28648871

1. INFORMATION AND CONSENT.

By accepting this Privacy Policy, the User is informed and gives their free, informed, specific and unequivocal consent so that the personal data provided through this website (hereinafter, the "Website") are processed by SEM.

2. OBLIGATORY TO PROVIDE THE DATA.

The data requested in the web forms are generally mandatory (unless otherwise specified in the required field) to fulfill the established purposes. Therefore, if they are not provided or are not provided correctly, they will not be able to be attended to, without prejudice to the fact that you can freely view the content of the Website.

3. FOR WHAT PURPOSE WILL THE USER'S PERSONAL DATA BE PROCESSED AND FOR HOW LONG?

The personal data provided through the Website will be processed by SEM in accordance with the following purposes:

  • Manage and process the registration requests of new members, from the "new members" forms, as well as manage the fees and derived charges.
  • Periodically send members, including by electronic means, information, events or news that may be of interest to them, if the future member gives their consent by checking the corresponding check box, or, where appropriate, opposes or revokes their consent.

4. WHAT USER DATA WILL BE PROCESSED?

SEM will process the following categories of User data:

  • Identification data: name, surname and ID.
  • Contact information: postal address, email address and telephone.
  • Professional data: workplace and professional contact details.
  • Academic data: degree and specialization.
  • Billing information.

5. WHAT IS THE LEGITIMATION OF THE PROCESSING OF USER DATA?

The treatment of the User's data by the SEM is based on the consent that is requested and that you can withdraw at any time. However, in case of withdrawing your consent, this will not affect the legality of the treatments carried out previously.
The consents obtained for the aforementioned purposes are independent so that the User may revoke only one of them, not affecting the others.

6. TO WHICH RECIPIENTS WILL THE USER DATA BE COMMUNICATED?

The data of the partners may be communicated to the following companies in the cases indicated:

• To the corresponding banking entities in order to manage the collection of direct debit bills.

The User's data will not be communicated to any other entity, except legal obligation.

7. RESPONSIBILITY OF THE USER.

The User and the Candidate for membership:
- Guarantees that you are over 18 years of age and that the data you provide to the SEM is true, accurate, complete and updated. For these purposes, the User is responsible for the veracity of all the data that he communicates and will keep the information provided suitably updated, in such a way that it responds to his real situation.
- You will be responsible for the false or inaccurate information that you provide through the Website and for the direct or indirect damages that this causes to the SEM or to third parties.

8. COMMUNICATIONS.

One of the purposes for which the SEM processes the personal data provided by Users is to send them electronic communications with information related to congresses and other events, grant programs, scientific dissemination, awards or relevant news for the recipients.
In the event that the recipient wishes to stop receiving informative communications from the SEM, they can request the cancellation of the service by sending an email to secretaria.sem@semicrobiologia.com or by clicking on the "unsubscribe" link included in the communications.

9. EXERCISE OF RIGHTS.

The User can send a letter at any time and free of charge to the SEM, Centro de Investigaciones Biológicas (CIB-CSIC) - c / Ramiro de Maeztu, 9 28040 Madrid, attaching a photocopy of their identity document, to request their rights of access, rectification, deletion, opposition, limitation, portability of your data.
You can also complain to the Spanish Agency for Data Protection, through the following address: Spanish Agency for Data Protection, C / Jorge Juan, 6, 28001-Madrid, when the interested party considers that the SEM has violated the rights that They are recognized by the applicable regulations on data protection.

10. SECURITY MEASURES.

The SEM will treat the data of Users, Candidates and Partners at all times in an absolutely confidential manner and keeping the mandatory duty of secrecy regarding them, in accordance with the provisions of the applicable regulations, adopting technical measures and measures for this purpose. necessary organizational measures that guarantee the security of your data and prevent its alteration, loss, treatment or unauthorized access, taking into account the state of technology, the nature of the stored data and the risks to which they are exposed.

:281-90. doi: 10.1111/j.1574-6941.2012.01391.x. Brucella