Group photo. Felix Sangari and Juan M Garcia Lobo
Felix Sangari and Juan M Garcia Lobo Brucella Felix Sangari and Juan M Garcia Lobohttp://web.unican.es/ibbtec/Felix Sangari and Juan M Garcia Lobo
Our main line of work is the investigation of the mechanisms of pathogenicity, or what has been the same, of the intracellular growth capacity of the important zoonotic agent Brucella.
Our main line of work is the investigation of the mechanisms of pathogenicity, or what has been the same, of the intracellular growth capacity of the important zoonotic agent Brucella They cause brucellosis, a zoonosis with significant repercussions on human animal health and which causes significant economic losses, with special repercussions in developing countries. In animals, which are their natural host, such as cows, goats or sheep, they mainly give rise to abortions and infertility, while in humans the disease manifests as a febrile syndrome that can progress to a chronic phase characterized by the appearance of severe complications such as endocarditis, arthralgia, epididymitis or neurobrucellosis. Brucellosis is endemic in areas such as Central and South America, the Middle East, the Mediterranean countries, North Africa, and the countries of the Caucasus and Central Asia. In Cantabria, an area with important cattle ranching under extensive management, occasional outbreaks still occur from time to time that require the sanitation of the affected herds, although the number of human cases is very low. However, the figure of some 500,000 new human cases each year is managed worldwide, a figure probably underestimated 4 or 5 times.
Our work on Brucella Our work on
Our work on Brucella Our work on2Our work on2 Our work on et al. 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of Brucella . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of
. 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of Brucella . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of . 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of. 2019). On the other hand, we have studied the role of a protein with lysozyme inhibitory activity, but which seems to play a relevant role in the survival of Brucella. For this we have used bioinformatic prediction methods together with different strategies with cell microbiology methodology using fluorescent surrogate effectors or by viral interference methods.
. For this we have used bioinformatic prediction methods together with different strategies with cell microbiology methodology using fluorescent surrogate effectors or by viral interference methods. Brucella. For this we have used bioinformatic prediction methods together with different strategies with cell microbiology methodology using fluorescent surrogate effectors or by viral interference methods.
Regarding the studies in the Altamira cave, of the different biological risks detected, the proliferation of "visible colonies" is the one considered most relevant and to which we are devoting our research effort.
The so-called visible colonies in quotes are biofilms or consortia of microorganisms, generally a few millimeters in size, visible and with different colors (grey, white, yellow) that grow on the walls and ceiling, especially in the outermost areas of Altamira. Since their first description around the year 2000, they have been the subject of numerous studies. After our incorporation to this work, we are contributing to a better description of the components of the consortia through massive sequencing studies. After a characterization by sequencing of 16S RNA amplicons, we have progressed to a stage of metagenomic analysis that is beginning to give interesting results. We have data on the bacteria that make up the majority consortia and their proportions in the different types of "colony" and we have obtained good quality drafts of the genomes of the majority components derived from metagenomic data.
With this information, which we want to complete with expression data (metatranscriptomes), we hope to be able to identify the most relevant aspects of the ecology of the consortia, identify the energy sources and the metabolic pathways involved.
The ultimate goal of this work is the design of safe control measures that serve to tackle a possible problem of biodeterioration due to the overproliferation of "colonies" but that do not cause collateral problems of alternative proliferation, as has happened previously in similar circumstances. This objective, which is quite complicated, will only be possible when we know in detail the eco-physiological aspects of these consortia, to which we are dedicating our efforts.
The ultimate goal of this work is the design of safe control measures that serve to tackle a possible problem of biodeterioration due to the overproliferation of "colonies" but that do not cause collateral problems of alternative proliferation, as has happened previously in similar circumstances. This objective, which is quite complicated, will only be possible when we know in detail the eco-physiological aspects of these consortia, to which we are dedicating our efforts.The ultimate goal of this work is the design of safe control measures that serve to tackle a possible problem of biodeterioration due to the overproliferation of "colonies" but that do not cause collateral problems of alternative proliferation, as has happened previously in similar circumstances. This objective, which is quite complicated, will only be possible when we know in detail the eco-physiological aspects of these consortia, to which we are dedicating our efforts.
References
The ultimate goal of this work is the design of safe control measures that serve to tackle a possible problem of biodeterioration due to the overproliferation of "colonies" but that do not cause collateral problems of alternative proliferation, as has happened previously in similar circumstances. This objective, which is quite complicated, will only be possible when we know in detail the eco-physiological aspects of these consortia, to which we are dedicating our efforts. (2014). Molecular Biology of the Pathogenicity of Brucella(2014). Molecular Biology of the Pathogenicity of
(2014). Molecular Biology of the Pathogenicity of (2014). Molecular Biology of the Pathogenicity of(2014). Molecular Biology of the Pathogenicity of
(2014). Molecular Biology of the Pathogenicity of(2014). Molecular Biology of the Pathogenicity of Brucella (2014). Molecular Biology of the Pathogenicity of2 (2014). Molecular Biology of the Pathogenicity of in vivo(2014). Molecular Biology of the Pathogenicity of
(2014). Molecular Biology of the Pathogenicity of(2014). Molecular Biology of the Pathogenicity of http://www.culturaydeporte.gob.es/mnaltamira/dam/jcr:23aff8fe-2c0c-474a-8db4-c34b644bcde9/conservacionpreventivaaltamira-informefinal-doc-investigacion.pdf
(2014). Molecular Biology of the Pathogenicity of(2014). Molecular Biology of the Pathogenicity of (2014). Molecular Biology of the Pathogenicity of:281-90. doi: 10.1111/j.1574-6941.2012.01391.x.